Fig 7. KPC34 is more effective against established CNS leukemia.

Kaplan-Meier curves for C57/Bl6 mice injected with B6-ALL syngeneic leukemia. Upon engraftment mice were treated with Ara-C at 7.1 mg/kg i.p. for four days and Dox at 3 mg/kg i.p. for three days. At the onset of hind limb paresis mice were treated with KPC34 at 20 mg/kg p.o. for 2 two days and followed. Once paresis returned mice were treated again.