Table 1. KPC34 is active against ALL in vitro in the nanomolar range.

Cell Line	Properties	KPC34 IC50 (95% CI)
B6-ALL (Ph+)	Murine B ALL, BCR-ABL, ARF-	10.36 nM (8.448–12.7)
SUPB15 (Ph+)	Human B cell ALL, BCR-ABL	7.39 nM (6.25–8.73)
Jurkat	Human T cell ALL	27.94 nM (22.88–34.12)
MOLT4	Human T cell ALL, heterozygous p53 (point missense mutation)	42.71 nM (32.59–55.96)
CCRF-CEM	Human T cell lymphoblastic ALL, compound heterozygote with two p53 point mutations	175.6 nM (146.8–210.0)