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. Author manuscript; available in PMC: 2017 Jun 23.
Published in final edited form as: Circ Res. 2008 Dec 12;104(2):236–244. doi: 10.1161/CIRCRESAHA.108.182014

Figure 1.

Figure 1

IL-6 Tg(+) mice have PAH at baseline that worsens with hypoxia. (a) RVSP is higher in Tg(+) mice (‡ vs. normoxic Tg(-);p<0.05; † vs. hypoxic Tg(-);p<0.05). (b) RV/LV+S are higher in IL-6 Tg(+) mice (‡ vs. normoxic Tg(-);p<0.05; † vs. hypoxic Tg(-);p<0.05). (c) RV weight is higher in IL-6 Tg(+) mice (‡ vs. normoxic Tg(-);p<0.05; † vs. hypoxic Tg(-);p<0.05) and increases further in hypoxia († vs. normoxic Tg(+);p<0.05) (d) Representative photomicrographs of IL-6 Tg(+) and Tg(-) mouse hearts in normoxic and hypoxic conditions. IL-6 Tg(+) mice right ventricles are hypertrophied at baseline and they hypertrophy further with hypoxia (hemotoxylin & eosin staining, magnification x25, bar=0.01mm).