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. Author manuscript; available in PMC: 2017 Jun 23.
Published in final edited form as: Circ Res. 2008 Dec 12;104(2):236–244. doi: 10.1161/CIRCRESAHA.108.182014

Figure 2.

Figure 2

Pulmonary artery (PA) tree of IL-6 Tg(+) mice has increased muscularization that worsens with hypoxia. (a-l) Representative photomicrographs of the elastic lamina of the PA vasculature of IL-6 Tg(+) and Tg(-) mice in normoxic and hypoxic conditions. Main PA branches (Tg(-) a, b vs. Tg(+) c, d), PA at the level of the terminal bronchioles (TB) (Tg(-) e, f, vs. Tg(+) g, h), PA distal to TB (acinar) (Tg(-) i, j vs. Tg(+) k, l). Elastic tissue stain, magnification x400, bar=0.001mm. (m-p) Representative photomicrographs of smooth muscle hypertrophy of distal acinar arterioles of the PA vasculature of IL-6 Tg(+) in normoxic and hypoxic conditions (Tg(-) m, n vs. Tg(+) o, p). Immunohistochemistry with α-smooth muscle actin, magnification x400, bar=0.001mm. (q-t) Thickness of the medial wall is increased at all levels of the PA tree of IL-6 Tg(+) mice compared to Tg(-) mice at baseline and worsens with hypoxia. (q) Number of elastic lamina of main PA branches (‡ vs. normoxic Tg(-);p<0.05, † vs. normoxic Tg(+);p<0.05, and † vs. hypoxic Tg(-);p<0.05). (r) Percent wall thickness (%WT) of the main PA branches (* vs. hypoxic Tg(-);p<0.05 and * vs. normoxic Tg(+);p<0.05. ‡ vs. normoxic Tg(-);p<0.05). (s) %WT of the TB PA vessels (* vs. hypoxic Tg(-);p<0.05, * vs. normoxic Tg(+);p<0.05, † vs. normoxic Tg(-);p<0.05, ‡ vs. normoxic Tg(-);p<0.05). (t) %WT of the acinar pulmonary arteriolar vessels († vs. normoxic Tg(-);p<0.05, ‡ vs. normoxic Tg(-);p<0.05, * vs. hypoxic Tg(-);p<0.05 and * vs. normoxic Tg(+);p<0.05).