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. Author manuscript; available in PMC: 2017 Jun 23.
Published in final edited form as: Circ Res. 2008 Dec 12;104(2):236–244. doi: 10.1161/CIRCRESAHA.108.182014

Figure 4.

Figure 4

Angioproliferative lesions are present in Tg(+) mice distal arterioles. (a-l) Representative photomicrographs showing the formation of thick occlusive neointimal lesions. Endothelial cells (Factor VIII) are forming thick layers in the distal acinar arterioles of Tg(+) mice (c and d) and have increased expression of vascular endothelial growth factor receptor 2 (VEGFR2: g and h) which was not seen in Tg(-) mice (a, b or e, f). There is increased cellular proliferation in the walls of the distal arterioles of IL-6 Tg(+) mice (PCNA: k and l) in normoxic and hypoxic conditions, which was not seen in Tg(-) mice (i and j). Immunohistochemistry staining, magnification x400, bar=0.001mm.