Table 2. Exome mutations, hTERT promoter mutations and G-allele status of anaplastic oligodendroglioma patients with short-term versus long-term survival treated with RT and PCV within NRG Oncology RTOG 9402.
| ST-1 | ST-2 | ST-3 | ST-4 | ST-5 | ST-6 | LT-1 | LT-2 | LT-3 | LT-4 | LT-5 | LT-6 | LT-7 | Added patient 1 | Added patient 2 | Total number mutated | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IDH1 | - | M | - | M | M | M | M | M | M | M | M | M | - | M | - | 11 |
| CIC | - | M | M | - | M | - | M | - | M | M | M | M | - | - | - | 8 |
| FUBP1 | - | - | - | - | M | - | - | M | M | M | M | - | M | M | M | 8 |
| NOTCH1 | - | - | M | - | - | - | - | M | - | - | - | - | - | - | M | 3 |
| NIPBL | M | - | M | - | - | - | - | M | - | - | - | - | - | - | - | 3 |
| ESX1 | - | - | M | - | - | - | - | - | - | - | M | M | - | - | - | 2 |
| PIK3CA | - | M | - | - | M | - | - | - | M | - | - | - | - | - | - | 3 |
| AC005014.2 | - | - | M | - | - | M | - | - | - | - | - | - | - | - | - | 2 |
| EIF3L | - | - | M | M | - | - | - | - | - | - | - | - | - | - | - | 2 |
| FAM83A | - | - | M | - | - | - | - | - | - | M | - | - | - | - | - | 2 |
| RIF1 | - | M | - | - | - | - | - | - | - | - | - | M | - | - | - | 2 |
| RLBP1L2 | - | - | M | M | - | - | - | - | - | - | - | - | - | - | - | 2 |
| TTN | - | M | - | - | - | - | M | - | - | - | - | - | - | - | - | 2 |
| EIF4B | - | - | - | - | - | - | - | - | - | - | - | - | - | - | M | 1 |
| EIF4E3 | - | - | - | - | M | - | - | - | - | - | - | - | - | - | - | 1 |
| EPC2 | - | - | - | - | M | - | - | - | - | - | - | - | - | - | - | 1 |
| KDM6B | - | - | - | - | M | - | - | - | - | - | - | - | - | - | - | 1 |
| ATRX | - | - | - | - | - | - | - | - | - | - | - | M | - | - | - | 1 |
| NOTCH2 | - | - | - | M | - | - | - | - | - | - | - | - | - | - | - | 1 |
| NOTCH3 | - | - | - | - | - | - | - | M | - | - | - | - | - | - | - | 1 |
| HOXD3 | - | - | - | - | - | - | - | - | M | - | - | - | - | - | - | 1 |
| EEF1G | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| EIF3L | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| EPHA7 | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| HDAC1 | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| MGMT | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| MLL | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| MLL2 | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| PIK3AP1 | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| TP53 | - | - | M | - | - | - | - | - | - | - | - | - | - | - | - | 1 |
| HDAC2 | - | - | - | - | - | - | M | - | - | - | - | - | - | - | - | 1 |
| G-Allele | AA | AA | AA | AA | GA | AA | GA | AA | AA | GA | AA | AA | GA | GA | AA | N/A |
| hTERT | - | M | M | M | M | M | M | M | M | M | M | M | - | M | M | |
| Survival (years) | 0.5 | 0.5 | 4.2 | 4.9 | 5.5 | 6.4 | 8 | 11.2 | 11.3 | 12 | 13.3 | 16.2 | 16.8 | 9.5 | 14.6 | |
| PFS (years) | 0.2 | 0.5 | 0.9 | 4.9 | 0.7 | 1.9 | 8 | 11.2 | 11.3 | 12 | 13.3 | 16.2 | 16.8 | 2.5 | 1.6 | |
| Progressive disease? | Yes | N/A* | Yes | N/A* | Yes | Yes | No | No | No | No | No | No | No | Yes | Yes |
Survival data for the individual patients are shown. PFS = Progression free survival. *Death, unrelated to disease progression.