Figure 3. Effects of COX2 over-expression or RNAi on the changes of depressive-like behaviors in CUMS-treated rats.

a. Effects of COX2 over-expressing lentivirus, LV-si-COX2 or LV-Mock (15 ul, 10 ⁸ TU/ml, intracerebroventricular injection, respectively) on the changes of body weight in CUMS-treated rats. b. Effects of COX2 over-expressing lentivirus, LV-si-COX2 or LV-Mock (15 ul, 10 ⁸ TU/ml, intracerebroventricular injection, respectively) on the changes of sucrose preference test in CUMS-treated rats. Each value represents the mean ± SD using a one-way ANOVA with a Bonferroni correction. **P < 0.01 vs control group. ^# and ^## P < 0.05 and < 0.01 vs the CUMS group. n = 10.