Figure 6. Changes of the concentration of inflammatory mediators in the hippocampus of CUMS rats upon inhibite the activity of COX2 or change the expression status of COX2.

a. The concentration of IL-6, TNF-α, PGE2 in the hippocampus of CUMS-treated rats after treatments of meloxicam (1 and 3mg/kg, i.g.), sertraline(5mg/kg, i.g.). b. The effects of COX2 over-expressing lentivirus, LV-si-COX2 or LV-Mock (15 ul, 10 ⁸ TU/ml) intracerebroventricular injection on the levels of IL-6, TNF-α, PGE2 in the hippocampus of CUMS-treated rats. Each value represents the mean ± SD using a one-way ANOVA with a Bonferroni correction. **P < 0.01 vs control group. ^# and ^## P < 0.05 and < 0.01 vs the CUMS group. n = 10.