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. 2017 Mar 8;8(22):35558–35572. doi: 10.18632/oncotarget.16009

Figure 9. Effects of COX2 RNAi and overexpression on the levels of COX2, EP3, cAMP, PKAIIα reg, p-CREB/CREB, and BDNF in the hippocampus of CUMS-treated rats.

Figure 9

a. Changes in the mRNA expression of COX2 in the hippocampus of CUMS rats after treatment with LV-Mock lentivirus, COX2 over-expressing or LV-si-COX2lentivirus (15 ul, 10 8 TU/ml, intracerebroventricular injection, respectively). The relative protein expressions of COX2 b., EP3 c., the content of cAMP d., the protien level of PKAIIα reg e., phosphorylated and total forms of CREB f., BDNF g. in the hippocampus of CUMS rats after treatment with LV-Mock lentivirus, COX2 over-expressing or LV-si-COX2 lentivirus (15 ul, 10 8 TU/ml, intracerebroventricular injection, respectively). Each value represents the mean ± SD using a one-way ANOVA with a Bonferroni correction. **P < 0.01 vs control group. # and ## P < 0.05 and < 0.01 vs the CUMS group. n = 10.

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