Table 7. Multivariate analysis of prognostic factors associated with overall survival.

Variable	HR (95% C.I.)	P - value
Baseline CTCs count ≥ 5 vs. < 5	3.451 (1.705 - 6.982)	0.0006
HER2 status Overexpressed vs. negative	0.372 (0.180 - 0.769)	0.0076
Hormone receptor status Positive for either vs. negative for both	0.213 (0.103 - 0.439)	< 0.00001
mDC_TNF-α_TLR High vs. low	3.114 (1.627 - 5.961)	0.0006
pDC_TNF-α_US High vs. low	0.499 (0.236 - 1.057)	0.0696

* all immune cells subpopulation were dichotomized as “low” or “high” based on median value of percentage of immunes cells in all patients.