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. 2017 Mar 16;8(22):35848–35862. doi: 10.18632/oncotarget.16261

Table 2. Association of DNA repair gene polymorphisms with GC risk.

HC Genotype GC Genotype Dominant model Recessive model Log-Additive model
Gen db SNP ID A/a H. pylori AA Aa aa AA Aa aa OR (95% CI)a P-value FDRb OR (95% CI)a P-value FDRb OR (95% CI)a P-value FDRb
TP53 rs1042522 G/C Overall n 314 247 40 372 192 39 0.67 (0.53–0.85) 0.001 0.012 1.05 (0.66–1.67) 0.832 0.896 0.78 (0.65–0.94) 0.009 0.068
H. pylori + 180 159 23 241 115 21 0.55 (0.41–0.74) 0.0001 0.002 0.85 (0.46–1.58) 0.619 0.734 0.65 (0.51–0.83) 0.001 0.013
H. pylori – 134 88 17 103 59 17 0.95 (0.64–1.41) 0.803 0.902 1.35 (0.66–2.74) 0.413 0.912 1.02 (0.76–1.39) 0.875 0.983
TP53 rs9894946 G/A Overall n 409 165 18 452 138 6 0.69 (0.53–0.90) 0.006 0.013 0.23 (0.08–0.68) 0.002 0.014 0.66 (0.52–0.85) 0.001 0.017
H. pylori + 249 98 11 288 82 3 0.65 (0.46–0.91) 0.019 0.095 0.27 (0.07–0.97) 0.021 0.143 0.64 (0.47–0.87) 0.004 0.053
H. pylori – 160 67 7 132 44 1 0.73 (0.47–1.14) 0.168 0.832 0.19 (0.02–1.57) 0.065 0.674 0.70 (0.47–1.05) 0.085 0.659
LIG3 rs2074522 G/A Overall n 509 89 2 496 94 13 1.22 (0.89–1.67) 0.217 0.268 7.05 (1.58–31.5) 0.001 0.014 1.32 (0.99–1.75) 0.055 0.080
H. pylori + 306 54 2 309 59 9 1.23 (0.83–1.81) 0.302 0.393 4.3 (0.92–20.28) 0.035 0.143 1.30 (0.92–1.85) 0.135 0.201
H. pylori – 203 35 148 27 4 1.16 (0.68–1.97) 0.591 0.902 NA NA 1.33 (0.80–2.11) 0.296 0.659
BRIP rs4986764 C/T Overall n 224 270 107 232 297 69 0.94 (0.74–1.20) 0.633 0.724 0.59 (0.42–0.83) 0.002 0.015 0.85 (0.72–1.00) 0.055 0.075
H. pylori + 134 166 64 145 188 42 0.93 (0.69–1.26) 0.657 0.603 0.58 (0.38–0.89) 0.011 0.143 0.84 (0.68–1.04) 0.106 0.180
H. pylori – 90 104 43 68 89 21 0.99 (0.66–1.48) 0.866 0.908 0.62 (0.35–1.09) 0.089 0.686 0.87 (0.66–1.16) 0.451 0.836

Notes: Stratified analysis by H. pylori infection status

HC, healthy control; GC, gastric cancer; n, number of individuals.

A/a, major/minor alleles; OR, odds ratio; CI, confidence interval; NA, not applied.

aP-values, ORs, and 95% CIs adjusted by gender, age, smoking habit, and family history of GC.

bQFDR-values obtained after applying the False Discovery Rate (FDR) test.

P-values < 0.05 are highlighted in bold.