Table 2. Association of DNA repair gene polymorphisms with GC risk.

			HC Genotype			GC Genotype			Dominant model		Recessive model		Log-Additive model
Gen db SNP ID		A/a	H. pylori	AA	Aa	aa	AA	Aa	aa	OR (95% CI)a P-value	FDRb	OR (95% CI)a P-value	FDRb	OR (95% CI)a P-value	FDRb
TP53 rs1042522		G/C	Overall n	314	247	40	372	192	39	0.67 (0.53–0.85) 0.001	0.012	1.05 (0.66–1.67) 0.832	0.896	0.78 (0.65–0.94) 0.009	0.068
			H. pylori +	180	159	23	241	115	21	0.55 (0.41–0.74) 0.0001	0.002	0.85 (0.46–1.58) 0.619	0.734	0.65 (0.51–0.83) 0.001	0.013
			H. pylori –	134	88	17	103	59	17	0.95 (0.64–1.41) 0.803	0.902	1.35 (0.66–2.74) 0.413	0.912	1.02 (0.76–1.39) 0.875	0.983
TP53 rs9894946		G/A	Overall n	409	165	18	452	138	6	0.69 (0.53–0.90) 0.006	0.013	0.23 (0.08–0.68) 0.002	0.014	0.66 (0.52–0.85) 0.001	0.017
			H. pylori +	249	98	11	288	82	3	0.65 (0.46–0.91) 0.019	0.095	0.27 (0.07–0.97) 0.021	0.143	0.64 (0.47–0.87) 0.004	0.053
			H. pylori –	160	67	7	132	44	1	0.73 (0.47–1.14) 0.168	0.832	0.19 (0.02–1.57) 0.065	0.674	0.70 (0.47–1.05) 0.085	0.659
LIG3 rs2074522		G/A	Overall n	509	89	2	496	94	13	1.22 (0.89–1.67) 0.217	0.268	7.05 (1.58–31.5) 0.001	0.014	1.32 (0.99–1.75) 0.055	0.080
			H. pylori +	306	54	2	309	59	9	1.23 (0.83–1.81) 0.302	0.393	4.3 (0.92–20.28) 0.035	0.143	1.30 (0.92–1.85) 0.135	0.201
			H. pylori –	203	35	–	148	27	4	1.16 (0.68–1.97) 0.591	0.902	NA	NA	1.33 (0.80–2.11) 0.296	0.659
BRIP rs4986764		C/T	Overall n	224	270	107	232	297	69	0.94 (0.74–1.20) 0.633	0.724	0.59 (0.42–0.83) 0.002	0.015	0.85 (0.72–1.00) 0.055	0.075
			H. pylori +	134	166	64	145	188	42	0.93 (0.69–1.26) 0.657	0.603	0.58 (0.38–0.89) 0.011	0.143	0.84 (0.68–1.04) 0.106	0.180
			H. pylori –	90	104	43	68	89	21	0.99 (0.66–1.48) 0.866	0.908	0.62 (0.35–1.09) 0.089	0.686	0.87 (0.66–1.16) 0.451	0.836

Notes: Stratified analysis by H. pylori infection status

HC, healthy control; GC, gastric cancer; n, number of individuals.

A/a, major/minor alleles; OR, odds ratio; CI, confidence interval; NA, not applied.

^aP-values, ORs, and 95% CIs adjusted by gender, age, smoking habit, and family history of GC.

^bQ_FDR-values obtained after applying the False Discovery Rate (FDR) test.

P-values < 0.05 are highlighted in bold.