Table 2. Association of DNA repair gene polymorphisms with GC risk.
HC Genotype | GC Genotype | Dominant model | Recessive model | Log-Additive model | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gen db SNP ID | A/a | H. pylori | AA | Aa | aa | AA | Aa | aa | OR (95% CI)a P-value | FDRb | OR (95% CI)a P-value | FDRb | OR (95% CI)a P-value | FDRb | |
TP53 rs1042522 | G/C | Overall n | 314 | 247 | 40 | 372 | 192 | 39 | 0.67 (0.53–0.85) 0.001 | 0.012 | 1.05 (0.66–1.67) 0.832 | 0.896 | 0.78 (0.65–0.94) 0.009 | 0.068 | |
H. pylori + | 180 | 159 | 23 | 241 | 115 | 21 | 0.55 (0.41–0.74) 0.0001 | 0.002 | 0.85 (0.46–1.58) 0.619 | 0.734 | 0.65 (0.51–0.83) 0.001 | 0.013 | |||
H. pylori – | 134 | 88 | 17 | 103 | 59 | 17 | 0.95 (0.64–1.41) 0.803 | 0.902 | 1.35 (0.66–2.74) 0.413 | 0.912 | 1.02 (0.76–1.39) 0.875 | 0.983 | |||
TP53 rs9894946 | G/A | Overall n | 409 | 165 | 18 | 452 | 138 | 6 | 0.69 (0.53–0.90) 0.006 | 0.013 | 0.23 (0.08–0.68) 0.002 | 0.014 | 0.66 (0.52–0.85) 0.001 | 0.017 | |
H. pylori + | 249 | 98 | 11 | 288 | 82 | 3 | 0.65 (0.46–0.91) 0.019 | 0.095 | 0.27 (0.07–0.97) 0.021 | 0.143 | 0.64 (0.47–0.87) 0.004 | 0.053 | |||
H. pylori – | 160 | 67 | 7 | 132 | 44 | 1 | 0.73 (0.47–1.14) 0.168 | 0.832 | 0.19 (0.02–1.57) 0.065 | 0.674 | 0.70 (0.47–1.05) 0.085 | 0.659 | |||
LIG3 rs2074522 | G/A | Overall n | 509 | 89 | 2 | 496 | 94 | 13 | 1.22 (0.89–1.67) 0.217 | 0.268 | 7.05 (1.58–31.5) 0.001 | 0.014 | 1.32 (0.99–1.75) 0.055 | 0.080 | |
H. pylori + | 306 | 54 | 2 | 309 | 59 | 9 | 1.23 (0.83–1.81) 0.302 | 0.393 | 4.3 (0.92–20.28) 0.035 | 0.143 | 1.30 (0.92–1.85) 0.135 | 0.201 | |||
H. pylori – | 203 | 35 | – | 148 | 27 | 4 | 1.16 (0.68–1.97) 0.591 | 0.902 | NA | NA | 1.33 (0.80–2.11) 0.296 | 0.659 | |||
BRIP rs4986764 | C/T | Overall n | 224 | 270 | 107 | 232 | 297 | 69 | 0.94 (0.74–1.20) 0.633 | 0.724 | 0.59 (0.42–0.83) 0.002 | 0.015 | 0.85 (0.72–1.00) 0.055 | 0.075 | |
H. pylori + | 134 | 166 | 64 | 145 | 188 | 42 | 0.93 (0.69–1.26) 0.657 | 0.603 | 0.58 (0.38–0.89) 0.011 | 0.143 | 0.84 (0.68–1.04) 0.106 | 0.180 | |||
H. pylori – | 90 | 104 | 43 | 68 | 89 | 21 | 0.99 (0.66–1.48) 0.866 | 0.908 | 0.62 (0.35–1.09) 0.089 | 0.686 | 0.87 (0.66–1.16) 0.451 | 0.836 |
Notes: Stratified analysis by H. pylori infection status
HC, healthy control; GC, gastric cancer; n, number of individuals.
A/a, major/minor alleles; OR, odds ratio; CI, confidence interval; NA, not applied.
aP-values, ORs, and 95% CIs adjusted by gender, age, smoking habit, and family history of GC.
bQFDR-values obtained after applying the False Discovery Rate (FDR) test.
P-values < 0.05 are highlighted in bold.