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. 2017 Mar 16;8(22):35890–35901. doi: 10.18632/oncotarget.16271

Figure 1. Different effects of pre-adipocytes and adipocytes on the biological behaviors of MDA-MB-231.

Figure 1

(A) Adipocytic differentiation of 3T3-L1 pre-adipocytes and Oil Red staining of mature adipocytes after differentiation induction (×400). (B) Oil Red staining of MDA-MB-231 cells (×400). (C) MTT assay was performed to detect the proliferation of MDA-MB-231 cells(*P < 0.05, **P < 0.01, vs control group). Result showed that pre-adipocytes and adipocytes could promot the proliferation of MDA-MB-231 cells. (D) and (E) Cell migration was evaluated by wound-closure assay (×100; *P < 0.05, **P < 0.01, ***P < 0.001, vs control group). F and G. The migration of MDA-MB-231 cells was evaluatedby transwell migration assay (×100; *P < 0.05, **P < 0.01, ***P < 0.001, vs control group). *P < 0.05, **P < 0.01, ***P < 0.001; vs control group. Control group: MDA-MB-231; Pre-adipocytes group: MDA-MB-231+ pre-adipocytes; Adipocytes group: MDA-MB-231+ adipocytes.