Table 4. Top 20 down-regulated genes of poorly differentiated HCC.

Entrez_ID	Gene Symbol	N1	N2	N3	T1	T2	T3	Group mean _exp_N	Group mean _exp_T	Group _log2FC	Group ttest _p value
83854	ANGPTL6	25.01	28.16	28.36	4.67	8.61	8.62	27.18	7.30	−1.76	1.44E-04
2706	GJB2	14.85	15.50	12.98	2.92	3.18	1.25	14.44	2.45	−2.16	2.00E-04
23002	DAAM1	5.54	5.70	6.63	1.39	1.70	2.41	5.96	1.83	−1.30	2.23E-04
8671	SLC4A4	10.64	9.24	9.18	2.04	1.21	1.14	9.68	1.46	−2.12	5.10E-04
389643	NUGGC	8.92	9.30	8.32	1.61	2.46	1.52	8.85	1.86	−1.78	5.44E-04
80824	DUSP16	18.19	15.58	14.62	8.60	6.06	5.75	16.13	6.80	−1.13	5.97E-04
1756	DMD	19.00	20.67	22.49	1.15	4.00	4.22	20.72	3.12	−2.40	7.46E-04
2244	FGB	4822.00	2846.01	2754.51	2475.77	484.91	192.48	3474.17	1051.05	−1.72	8.24E-04
56907	SPIRE1	3.97	5.48	6.04	0.96	2.07	2.81	5.17	1.95	−1.06	1.29E-03
283537	SLC46A3	39.62	40.22	43.44	4.31	1.39	8.81	41.09	4.84	−2.85	1.29E-03
132671	SPATA18	2.87	2.41	2.67	0.12	0.02	0.20	2.65	0.11	−1.71	1.81E-03
1003	CDH5	14.79	13.86	23.11	2.30	1.73	9.11	17.25	4.38	−1.76	1.97E-03
4051	CYP4F3	116.69	77.42	71.59	57.44	8.09	7.12	88.57	24.21	−1.83	2.04E-03
9953	HS3ST3B1	5.67	5.24	4.49	0.63	0.47	0.18	5.13	0.43	−2.10	2.05E-03
10894	LYVE1	43.68	40.34	38.97	0.56	3.11	0.76	41.00	1.48	−4.08	2.12E-03
57188	ADAMTSL3	5.57	4.39	4.54	1.40	0.08	0.87	4.83	0.78	−1.71	2.25E-03
152926	PPM1K	3.52	3.35	4.35	0.93	0.81	1.39	3.74	1.04	−1.21	2.27E-03
8658	TNKS	6.36	5.58	6.40	2.33	2.03	2.20	6.11	2.19	−1.16	2.44E-03
116519	APOA5	208.64	134.96	119.75	88.24	9.53	14.19	154.45	37.32	−2.02	2.58E-03
90417	KNSTRN	2.17	3.28	4.17	7.96	6.80	8.81	3.21	7.85	1.07	1.94E-02

Note: T1, T2, T3 represent tumor tissue of P1, P2, P3 with poorly differentiated HCC, respectively; N1, N2, N3 represent adjacent non-tumor tissue of P1, P2, P3 with poorly differentiated HCC, respectively.