Figure 7. Nutrient-sensing pathways in the liver of animals fed either AL or CR diet for 17 months, followed by AL feeding for 3 months (see Figure 3 for experimental details).

(A) reports WB analysis for the expression of SIRT1, HDCA1, C/EBPβ and FOXO1, while in (B) the corresponding densitometries with reference to actin is presented. Significantly different from control: *p < 0.05; **p < 0.01; ***p < 0.001.