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. 2017 Mar 21;8(22):36099–36114. doi: 10.18632/oncotarget.16432

Figure 6. Orthotopic animal experiments for intravesical collagen blockade therapeutic approach.

Figure 6

(A) Experimental design used in this study. (B) After completion of treatment, resected bladders from each group (n = 5/group) were subjected to H&E staining. Pathological diagnoses of NC siRNA-treated bladder tumors and COLs siRNA-treated bladder tumors were compared in two UCB cell lines. (C) Representative H&E images of NC siRNA-treated bladder tumor and COLs siRNA-treated bladder tumors demonstrated inhibition of the formation of the infiltrative growth pattern following COLs siRNA treatment. All images were captured at 100× and 400× magnification. (D) Representative image of immunohistochemical staining of NC siRNA-treated bladder tumor and COLs siRNA-treated bladder tumors. The images demonstrate the modulation of proteins related to the expression of COLs. All images were captured at 100× magnification.