Figure 3. GGT levels are correlated with chemo-resistance of gastric cancer and validation on public databases.
(A, B) Serum GGT level are marginally associated PFS (p=0.05) in gastric cancer patients who received 5-Fu and platinum based chemotherapy, but tumor GGT expression is not significantly correlated with PFS (p=0.24); (C, D) The result was further validated in a pooled analysis of six GEO datasets which were assembled inwww.kmplot.com. In validation dataset there are 876 patients’ information and gene expression data available. Patients with high GGT expression showed significant poor overall survival compare to low GGT expression patients. *All the probes are normalized and dichotomized according to previous publication [45].