Table 1. Correlations between clinic-pathological features of GC patients with tumor and serum GGT expression.
| GGT | sGGT | ||||||
|---|---|---|---|---|---|---|---|
| Cases | %of GGT(+)a | P value | Cases | %of sGGT (+)a | P value | ||
| Age | |||||||
| <60 | 160 | 36 (22.5) | 109 | 30(27.5) | |||
| >=60 | 162 | 46 (28.4) | 0.22 | 130 | 35(26.9) | 0.92 | |
| Sex | |||||||
| Male | 217 | 64 (29.5) | 168 | 48(27.4) | |||
| Female | 105 | 18 (17.1) | *0.02 | 71 | 17(26.6) | 0.89 | |
| Location of tumorb | |||||||
| Proximalc | 59 | 14 (23.7) | 40 | 10(25.0) | |||
| Bodyd | 67 | 25 (37.3) | 53 | 18(34.0) | |||
| Distale | 175 | 38 (21.7) | 135 | 31(23.0) | |||
| Wholef | 11 | 3 (27.3) | 0.11 | 7 | 3(42.1) | 0.36 | |
| TNM stagesb | |||||||
| Stage I & II | 138 | 31 (22.5) | 126 | 31(24.6) | |||
| Stage III &IV | 178 | 49 (27.5) | 0.3 | 111 | 32(28.8) | 0.46 | |
| Invasion Depthb | |||||||
| T1&T2 | 80 | 18 (22.5) | 85 | 20(23.5) | |||
| T3&T4 | 236 | 62 (26.3) | 0.5 | 150 | 42(28.0) | 0.45 | |
| Lymph nodeb | |||||||
| Negative | 86 | 14 (16.3) | 86 | 21(24.4) | |||
| Positive | 224 | 65 (29.0) | *0.017 | 148 | 40(27.0) | 0.66 | |
| Distant Metastasis | |||||||
| No | 281 | 67 (23.8) | 212 | 55(25.9) | |||
| Yes | 41 | 15 (36.6) | 0.09 | 27 | 10(37.0) | 0.24 | |
| Tumor grade | |||||||
| Low (G1) | 42 | 16 (38.1) | 46 | 10(21.7) | |||
| Moderate (G2) | 78 | 20 (25.6) | 57 | 13(22.8) | |||
| High (G3 & G4) | 202 | 46 (22.8) | 0.13 | 136 | 42(30.9) | 0.33 | |
| Histological type | |||||||
| Papillary & Tubular | 74 | 26(35.1) | 69 | 20(29.0) | |||
| Mucinous & Signet Ring Cell | 81 | 13(16.1) | 59 | 10(17.0) | |||
| Poor differentiated | 167 | 45(27.0) | *0.02 | 110 | 34(30.9) | 0.12 | |
| Vascular Invasion | |||||||
| Yes | 24 | 14 (58.3) | 36 | 59(26.7) | |||
| No | 274 | 114 (41.6) | 0.11 | 196 | 6(33.3) | 0.55 | |
| Tumor Nodular Formation | |||||||
| Yes | 48 | 18(23.0) | 30 | 5(16.7) | |||
| No | 261 | 60(37.5) | *0.04 | 202 | 56(27.7) | 0.18 | |
| Lesion Size (Largest dimension) | |||||||
| <5 cm | 126 | 29 (23.0) | 128 | 34(26.6) | |||
| >=5cm | 177 | 46 (26.0) | 0.55 | 105 | 27(25.7) | 0.88 | |
| Her2 expression | |||||||
| Negative | 94 | 35 (37.2) | 136 | 38(27.9) | |||
| Positive | 185 | 38 (20.5) | *0.003 | 43 | 7(16.3) | 0.11 | |
| Ki67 Index | |||||||
| Low | 85 | 20 (23.5) | 110 | 10(23.3) | |||
| High | 172 | 47 (27.3) | 0.51 | 43 | 28(25.5) | 0.78 | |
NOTE: All samples were collected from Zhejiang University. All information about TNM stage (tumor) were based on the pathological report of surgical specimens according to NCCN gastric cancer guideline v 2011.2
a GGT(+) means immunohistochemical staining score 2+ and 3+, and sGGT(+) means serum GGT level >24 pg/ml.
b All missing cases were appropriately coded as “missing value”
c Proximal stomach includes: Cardia, GEJ, Esophagus lower, fundus.
d Body stomach includes: lesser curve, greater curve, stomach overlapping, body.
e Distal stomach includes: Gastric antrum, pylorus
f Whole stomach indicates: linitis plastica
* indicates p<0.01, statistical significance.