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. 2017 Mar 11;8(22):36246–36265. doi: 10.18632/oncotarget.16121

Figure 2. NMU mRNA expression in an independent breast cancer cohort and its clinical impact in advanced tumor stages.

Figure 2

(A) In silico NMU mRNA expression analysis of 830 PAM50-defined breast tumor samples and 113 normal breast tissues depicted as heat map. Red color: high, black: intermediate, green: low NMU mRNA expression. (B) Box plot demonstrating breast cancer subtype-specific NMU mRNA expression. Horizontal lines: grouped medians. Boxes: 25-75% quartiles. Vertical lines: range, minimum and maximum. *** P < 0.001; ns: not significant (Kruskal-Wallis test). (C) NMU mRNA expression is elevated in larger breast tumors. Horizontal lines: grouped medians. Boxes: 25-75% quartiles. Vertical lines: range, minimum and maximum (Mann-Whitney-U test). (D-G) Univariate Kaplan-Meier survival curves displaying overall survival (OS) of patients with high NMU (>median expression) expression (green line) in relation to low NMU (≤ median expression) expression (blue line) in pT1 (D) and in pT2-4 tumors (E). (F-G) Univariate Kaplan-Meier survival curves displaying overall survival (OS) of patients with high NMU (>median expression) expression (green line) in relation to low NMU (≤ median expression) expression (blue line) in pN-negative (F) and in pN-positive tumors (G).