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. 2017 Mar 31;8(22):36305–36318. doi: 10.18632/oncotarget.16750

Table 6. Univariate and multivariate analyses of disease-free survival.

Variable Category Univariate analysis Multivariate analysis
Hazard ratio 95% CI p value Hazard ratio 95% CI p value
Whole group
T stage T1 vs. T2-4 1.750 0.826–3.706 0.144 1.219 0.561–2.653 0.617
N stage N0 vs. N1-3 2.468 1.147–5.311 0.021 2.715 1.254–5.875 0.011
Histologic grade I vs. II & III 5.099 0.694–37.488 0.109 4.247 0.570–31.626 0.158
LVI Absent vs. Present 2.735 1.245–6.008 0.012 1.984 0.840–4.687 0.118
Oct4 Negative vs. Positive 2.522 1.148–5.542 0.021 2.542 1.144–5.647 0.022
Hormone receptor-positive group
T stage T1 vs. T2-4 2.546 1.027–6.309 0.044 2.067 0.827–5.168 0.120
N stage N0 vs. N1-3 3.606 1.320–9.852 0.012 4.443 1.613–12.236 0.004
Histologic grade I vs. II & III 5.533 0.742–41.246 0.095 2.789 0.352–22.089 0.331
LVI Absent vs. Present 2.167 0.874–5.374 0.095 1.053 0.398–2.786 0.918
Oct4 Negative vs. Positive 6.346 2.662–15.128 <0.001 7.782 3.226–18.772 < 0.001
Hormone receptor-positive group treated with tamoxifen
T stage T1 vs. T2-4 2.029 0.772–5.334 0.151 1.755 0.658–4.678 0.261
N stage N0 vs. N1-3 2.847 1.003–8.083 0.049 3.729 1.291–10.769 0.015
Histologic grade I vs. II & III 3.246 0.430–24.504 0.254 1.434 0.175–11.720 0.737
LVI Absent vs. Present 1.443 0.549–3.792 0.457 0.912 0.336–2.477 0.857
Oct4 Negative vs. Positive 5.662 2.179–14.716 <0.001 7.115 2.683–18.870 < 0.001

P values were calculated by Cox proportional hazards regression model with a backward stepwise selection method.

CI, confidence interval; LVI, lymphovascular invasion.