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. 2017 Apr 4;8(22):36399–36409. doi: 10.18632/oncotarget.16821

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Copyright: © 2017 Han and Choi

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Effect of NBP on the mineralization of extracellular matrix by MC3T3-E1 cells (A) and SaOS-1 cells (B). Osteoblastic cells were exposed to NBP for various time with or without OI medium and von Kossa staining (A and B) was performed to demonstrate mineralized nodule formation at days 10. Both the SaOS-2 plasma and MC3T3-E1 plasma combined with OI media groups showed significant differences by one-way ANOVA that group F_(7.581) = 0.655, p = 0.0042, p < 0.01. Quantitative analysis of ARS performed by determine absorbance at 450 nm wavelength (C). MC3T3-E1 cells were treated with NBP with or without OI medium and ALP activity was measured by absorbance at 405 nm (D). Compared all groups showed significant differences by one-way ANOVA: group F_(313.8) = 0.9874, P < 0.0001 But there is no difference between plasma and plasma with OI group.