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. 2017 Apr 5;8(22):36449–36461. doi: 10.18632/oncotarget.16860

Figure 1. Resveratrol improved the survival, renal function and structure damage of rats with polymicrobial sepsis-induced AKI.

Figure 1

A rat model of polymicrobial sepsis-induced AKI was established by CLP operation, 30 mg/kg resveratrol was intraperitoneally administrated immediately after CLP operation. (A and B)At 12 hours after CLP operation, the blood urea nitrogen (A) and serum creatinine (B) levels were detected (n = 5 per group). (C) At 12 hours after CLP operation, the renal morphology was detected by HE staining (×100). (D) At 12 hours after CLP operation, the mRNA expressions of HO-1, KIM-1 and NGAL in the kidney were detected by RT-PCR (n = 5 per group). (D) Kaplan–Meier test was performed to analyze the survival of rats (n = 20 per group). Note: *p < 0.05 vs. Sham group, #p < 0.05 vs. CLP group.