Table 3. Univariable and multivariable Cox regression models to predict OS in 481 patients treated with radical nephroureterectomy for UTUC.
| Variables | CSS Multivariable | ||
|---|---|---|---|
| p Value | HR (95%CI) | p Value | |
| Age (years) | <0.001 | ||
| <65 | Reference | ||
| ≥65 | 2.38(1.62-3.50) | <0.001 | |
| Gender | 0.987 | ||
| Male | |||
| Female | |||
| Hypertension | 0.784 | ||
| No | |||
| Yes | |||
| Diabetes mellitus | 0.004 | - | |
| No | |||
| Yes | |||
| Multifocality | 0.001 | ||
| No | Reference | ||
| Yes | 1.49(1.02-2.19) | 0.040 | |
| pTNM stage | |||
| T stage | <0.001 | ||
| Ta-1 | Reference | ||
| T2-4 | 2.17(1.45-3.24) | <0.001 | |
| N stage | <0.001 | ||
| Nx/0 | Reference | ||
| N1-3 | 1.71(0.96-3.04) | 0.070 | |
| WHO Grade | <0.001 | ||
| Low | Reference | ||
| High | 1.65(1.09-2.52) | 0.019 | |
| LVI | <0.001 | ||
| No | Reference | ||
| Yes | 1.43(0.97-2.09) | 0.071 | |
| Adjuvant Chemotherapy | 0.665 | ||
| No | |||
| Yes | |||
| F-PLR score | <0.001 | ||
| 0 | Reference | ||
| 1 | 2.39(1.68-3.39) | <0.001 | |
| 2 | 3.78(1.81-7.89) | <0.001 | |