Table 4. Multivariable model of possible independent prognostic variables for CSS in UTUC patients.

Co-Variable	Multivariable	P Value	Multivariable	P Value	Multivariable	P Value	Multivariable	P Value	Multivariable	P Value
	HR(95%CI)		HR(95%CI)		HR(95%CI)		HR(95%CI)		HR(95%CI)
Age (≥65 vs<65 years)	2.07(1.37-3.14)	0.001	1.99(1.31-3.02)	0.001	2.04(1.34-3.09)	0.001	2.03(1.34-3.08)	0.001	1.96(1.29-2.99)	0.002
Multifocality(yes vs no)	1.95(1.29-2.95)	0.002	1.78(1.18-2.70)	0.007	1.85(1.21-2.82)	0.005	1.79(1.18-2.72)	0.006	1.66(1.09-2.53)	0.018
pT (2-4vs a,1)	3.19(2.00-5.12)	<0.001	2.68(1.64-4.36)	<0.001	3.16(1.97-5.06)	<0.001	3.01(1.87-4.83)	<0.001	2.75(1.70-4.45)	<0.001
pN(1-3 vs x/0)	1.83(0.99-3.39)	0.054	1.57(0.84-2.93)	0.16	1.72(0.92-3.21)	0.089	1.67(0.90-3.10)	0.108	1.39(0.73-2.65)	0.31
Grade (High vs Low)	2.12(1.27-3.56)	0.004	2.02(1.19-3.43)	0.009	2.15(1.28-3.60)	0.004	2.21(1.32-3.71)	0.003	2.08(1.23-3.51)	0.006
LVI (yes vs no)	1.72(1.14-2.59)	0.01	1.72(1.14-2.59)	0.01	1.64(1.08-2.49)	0.021	1.72(1.14-2.59)	0.01	1.54(1.01-2.34)	0.045
Fibrinogen level (>4.22 vs ≤4.22)			2.56(1.75-3.76)	<0.001
PLR (>241.2 vs ≤241.2)					1.53(0.84-2.79)	0.161
NLR (>3.22 vs ≤3.22)							1.73(1.18-2.54)	0.005
F-RLR score (2 vs 1 vs 0)									2.21(1.61-3.03)	<0.001
Predictive Accuracy (%)	77.2		79.4		77.5		77.9		79.9