Table 2. Meta-analysis of the association between PDCD1 polymorphisms and systemic lupus erythematosus risk.
| Comparisons | OR | 95%CI | P value | Heterogeneity | Effects model | |
|---|---|---|---|---|---|---|
| I2 | P value | |||||
| B vs A | ||||||
| PD1.1 | 1.23 | 0.82–1.84 | 0.31 | 54% | 0.07 | R |
| PD1.2 | 0.80 | 0.49-1.29 | 0.36 | 78% | 0.00 | R |
| PD1.3 | 1.35 | 1.12-1.63 | 0.00 | 57% | 0.00 | R |
| Caucasian | 1.27 | 1.05-1.57 | 0.02 | 62% | 0.00 | R |
| Mixed | 2.92 | 1.76-4.86 | 0.00 | 0% | 0.74 | F |
| African | 2.25 | 0.64-7.96 | 0.21 | 0% | 0.92 | F |
| Asian | 0.97 | 0.59-1.62 | 0.92 | 0% | 0.91 | F |
| PD1.3(gender) | 1.36 | 0.98- 1.87 | 0.06 | 71% | 0.00 | R |
| Female | 1.04 | 0.78- 1.40 | 0.78 | 59% | 0.01 | R |
| Male | 2.09 | 1.06- 4.12 | 0.03 | 70% | 0.00 | R |
| PD1.5 | 1.07 | 0.88-1.30 | 0.49 | 62% | 0.00 | R |
| Caucasian | 0.85 | 0.69-1.04 | 0.11 | 0% | 0.84 | F |
| Mixed | 1.10 | 0.82-1.48 | 0.54 | 44% | 0.18 | F |
| Asian | 1.18 | 0.80-1.75 | 0.41 | 76% | 0.00 | R |
| PD1.6 | 0.84 | 0.73-0.96 | 0.01 | 22% | 0.21 | F |
| Caucasian | 0.85 | 0.63-1.13 | 0.25 | 14% | 0.32 | F |
| Mixed | 0.84 | 0.69-1.02 | 0.09 | 0% | 0.56 | F |
| Asian | 0.84 | 0.63-1.12 | 0.23 | 56% | 0.04 | R |
| BB vs AA | ||||||
| PD1.1 | 1.19 | 0.75-1.88 | 0.46 | 0% | 0.77 | F |
| PD1.2 | 0.80 | 0.36-1.78 | 0.59 | 51% | 0.10 | F |
| PD1.3 | 1.30 | 0.59- 2.89 | 0.52 | 0% | 0.62 | F |
| PD1.5 | 0.87 | 0.60- 1.27 | 0.47 | 0% | 0.71 | F |
| PD1.6 | 0.79 | 0.54-1.17 | 0.24 | 16% | 0.30 | F |
| Caucasian | 1.20 | 0.35-4.17 | 0.77 | 0% | 0.78 | F |
| Asian | 0.71 | 0.36-1.41 | 0.33 | 44% | 0.11 | F |
| AB vs AA | ||||||
| PD1.1 | 1.32 | 0.73-2.38 | 0.36 | 53% | 0.08 | R |
| PD1.2 | 1.23 | 0.78-1.94 | 0.37 | 0% | 0.85 | F |
| PD1.3 | 1.41 | 1.12- 1.76 | 0.00 | 19% | 0.26 | F |
| Caucasian | 1.37 | 1.06- 1.76 | 0.02 | 27% | 0.24 | F |
| Asian | 0.97 | 0.55- 1.71 | 0.93 | 0% | 0.89 | F |
| PD1.5 | 1.27 | 0.80-2.00 | 0.31 | 80% | 0.00 | R |
| PD1.6 | 0.91 | 0.70-1.19 | 0.50 | 0% | 0.89 | F |
| Caucasian | 1.05 | 0.63-1.75 | 0.85 | 0% | 0.97 | F |
| Asian | 0.75 | 0.48-1.17 | 0.21 | 0% | 0.80 | F |
| BB+AB vs AA | ||||||
| PD1.1 | 1.36 | 0.77-2.41 | 0.30 | 55% | 0.06 | R |
| PD1.2 | 0.99 | 0.64-1.53 | 0.96 | 0% | 0.40 | F |
| PD1.3 | 1.41 | 1.13-1.77 | 0.00 | 22% | 0.23 | F |
| Caucasian | 1.38 | 1.06-1.78 | 0.02 | 32% | 0.21 | F |
| Asian | 0.97 | 0.56-1.69 | 0.92 | 0% | 0.90 | F |
| PD1.5 | 1.24 | 0.80-1.91 | 0.34 | 79% | 0.00 | R |
| PD1.6 | 0.90 | 0.70-1.15 | 0.40 | 0% | 0.63 | F |
| Caucasian | 1.08 | 0.66-1.75 | 0.77 | 0% | 0.96 | F |
| Asian | 0.77 | 0.50-1.20 | 0.25 | 4% | 0.39 | F |
| BB vs AB+AA | ||||||
| PD1.1 | 1.13 | 0.77-1.65 | 0.53 | 0% | 0.90 | F |
| PD1.2 | 0.63 | 0.33-1.22 | 0.17 | 74% | 0.01 | R |
| PD1.3 | 1.26 | 0.57-2.79 | 0.57 | 0% | 0.63 | F |
| PD1.5 | 0.84 | 0.59- 1.20 | 0.33 | 0% | 0.57 | F |
| PD1.6 | 0.80 | 0.62-1.04 | 0.10 | 30% | 0.18 | F |
| Caucasian | 1.19 | 0.35-4.09 | 0.79 | 0.0% | 0.78 | F |
| Asian | 0.82 | 0.56-1.20 | 0.31 | 54% | 0.05 | R |
A: the major allele, B: the minor allele, F: fixed effects model, R: random effects model.