Table 2. RAS and BRAF mutation status.

	Study population
Genotype	Total (n=457) n (%)	Arm A (n=146) n (%)	Arm B (n=158) n (%)	Arm C (n=153) n (%)
Wild-type (RAS and BRAF)	192 (42.0)	64 (43.8)	66 (41.8)	62 (40.5)
RAS mutant	210 (46.0)	63 (43.2)	72 (45.6)	75 (49.0)
KRAS exon 2 mutant	179 (39.2)	55 (37.7)	67 (42.4)	57 (37.3)
KRAS G12A	16 (3.5)	5 (3.4)	5 (3.2)	6 (3.9)
KRAS G12R	3 (0.7)	1 (0.7)	1 (0.6)	1 (0.7)
KRAS G12D	62 (13.6)	14 (9.6)	27 (17.1)	21 (13.7)
KRAS G12C	16 (3.5)	4 (2.7)	7 (4.4)	5 (3.3)
KRAS G12S	11 (2.4)	5 (3.4)	4 (2.5)	2 (1.3)
KRAS G12V	30 (6.6)	11 (7.5)	11(7.0)	8 (5.2)
KRAS G13D	41 (9.0)	15 (10.3)	12 (7.6)	14 (9.2)
KRAS exon 3 mutant	9 (2.0)	2 (1.4)	2 (1.3)	5 (3.3)
KRAS Q61H	3 (0.7)	0	1 (0.6)	2 (1.3)
KRAS Q61L	5 (1.1)	2 (1.4)	1 (0.6)	2 (1.3)
KRAS Q61R	1 (0.2)	0	0	1 (0.7)
KRAS exon 4 mutant	7 (1.5)	2 (1.4)	1 (0.6)	4 (2.6)
KRAS K117X	1 (0.2)	0	0	1 (0.7)
KRAS A146X	6 (1.3)	2 (1.4)	1 (0.6)	3 (2.0)
NRAS exon 2 mutant	8 (1.8)	2 (1.4)	1 (0.6)	5 (3.3)
NRAS G12S	1 (0.2)	1 (0.7)	0	0
NRAS G12C	6 (1.3)	0	1 (0.6)	5 (3.3)
NRAS G13V	1 (0.2)	1 (0.7)	0	0
NRAS exon 3 mutant	7 (1.5)	2 (1.4)	1 (0.6)	4 (2.6)
NRAS Q61L	2 (0.4)	0	0	2 (1.3)
NRAS Q61K	3 (0.7)	1 (0.7)	1 (0.6)	1 (0.7)
NRAS Q61R	2 (0.4)	1 (0.7)	0	1 (0.7)
BRAF mutant (V600E)	55 (12.0)	19 (13.0)	20 (12.7)	16 (10.5)