Table 2. Associations between inflammatory markers and risk of CRC.

Marker	n CRC/n total	Hazard ratio (95% CI)a	Hazard ratio (95% CI)b	Hazard ratio (95%)c
CRP (mg l−1)
Continuous logd	295/17 852	0.91 (0.77–1.07)	0.85 (0.72–1.01)	0.87 (0.73–1.04)
<10	3930/27 9599	1 (reference)	1 (reference)	1 (reference)
10–15	635/33 556	1.12 (1.03–1.22)	1.02 (0.94–1.11)	1.03 (0.90–1.34)
15–25	104/6053	1.26 (1.04–1.53)	1.11 (0.92–1.35)	1.10 (0.90–1.34)
25–50	57/3953	1.05 (0.81–1.36)	0.88 (0.68–1.14)	0.93 (0.72–1.21)
>50	38/2438	1.14 (0.83–1.57)	0.89(0.65–1.23)	0.88 (0.63–1.23)
Ptrend		<0.01	0.8	1
Albumin (g l−1)
Continuous log	4764/32 5599	0.02 (0.01–0.03)	0.69 (0.43–1.09)	0.58 (0.36–0.95)
<41	1065/51 719	1 (reference)	1 (reference)	1 (reference)
41–43	1365/74 713	0.85(0.79–0.92)	1.00 (0.92–1.08)	1.00 (0.92–1.08)
43–45	1290/90 321	0.67 (0.67–0.62)	0.95 (0.87–1.03)	0.94 (0.86–1.02)
>45	1044/108 846	0.47 (0.47–0.43)	0.93 (0.85–1.02)	0.91 (0.83–1.00)
Ptrend		<0.0001	0.06	0.02
Haptoglobin (g l−1)
Continuous log	3645/218 158	2.01 (1.86–2.36)	1.28 (1.14–1.44)	1.24 (1.10–1.40)
<0.90	704/53 597	1 (reference)	1 (reference)	1 (reference)
0.90–1.00	470/30 725	1.19 (1.06–1.34)	1.083 (0.96–1.22)	1.09 (0.97–1.22)
1.00–1.20	1090/66 060	1.31 (1.19–1.44)	1.07 (0.97–1.18)	1.06 (0.96–1.17)
>1.20	1381/67 776	1.70 (1.56–1.86)	1.19 (1.09–1.31)	1.17 (1.06–1.28)
Ptrend		<0.0001	0.0002	0.002
Leukocytes (109/l)
Continuous log	1392/96 821	1.322 (1.10–1.56)	1.37 (1.13–1.65)	1.30 (1.07–1.58)
<5.20	284/22 495	1 (reference)	1 (reference)	1 (reference)
5.2–6.3	355/25 147	1.15 (0.98–1.34)	1.10 (0.94–1.28)	1.08 (0.92–1.27)
6.3–7.6	386/24 223	1.32 (1.13–1.54)	1.24 (1.06–1.45)	1.22 (1.04–1.43)
>7.6	367/24 956	1.23 (1.07–1.45)	1.25 (1.07–1.46)	1.21 (1.03–1.42)
Ptrend		0.002	0.002	0.008

Abbreviations: CRC=colorectal cancer; CRP=C-reactive protein; UC=ulcerative colitis.

^aCrude model.

^bAdjusted for age, sex, education and socioeconomic status, Charlson comorbidity index and UC.

^cAdjusted for age, sex, education and socioeconomic status, Charlson comorbidity index and UC, glucose, total cholesterol and triglycerides.

^dCRP>10 mg l⁻¹.