Table 3. Regression coefficients (r) of the multiple regression analysis for DOS–GLCM features and corresponding regression.
| DOS–GLCM feature | Comparison | r | F-value | P-value |
|---|---|---|---|---|
| Hb-homogeneity | Age | −0.130 | 0.599 | 0.444 |
| ER/PR status | −0.087 | 0.267 | 0.608 | |
| Her2 status | −0.104 | 0.382 | 0.540 | |
| Tumour size | +0.231 | 1.967 | 0.170 | |
| Miller–Payne grade | −0.358 | 5.137 | 0.030 | |
| HbO2-correlation | Age | −0.116 | 0.475 | 0.495 |
| ER/PR status | −0.003 | 0.000 | 0.988 | |
| Her2 status | −0.109 | 0.418 | 0.522 | |
| Tumour size | −0.295 | 3.335 | 0.076 | |
| Miller–Payne grade | +0.375 | 5.172 | 0.022 | |
| HbT-homogeneity | Age | −0.142 | 0.715 | 0.403 |
| ER/PR status | +0.007 | 0.002 | 0.969 | |
| Her2 status | +0.206 | 1.544 | 0.222 | |
| Tumour size | +0.085 | 0.257 | 0.616 | |
| Miller–Payne grade | −0.233 | 2.015 | 0.165 | |
| St-contrast | Age | −0.231 | 1.972 | 0.169 |
| ER/PR status | +0.056 | 0.111 | 0.741 | |
| Her2 status | +0.095 | 0.322 | 0.574 | |
| Tumour size | −0.164 | 0.971 | 0.331 | |
| Miller–Payne grade | +0.177 | 1.138 | 0.293 | |
| StO2-contrast | Age | −0.083 | 0.241 | 0.626 |
| ER/PR status | −0.074 | 0.190 | 0.665 | |
| Her2 status | −0.213 | 1.661 | 0.206 | |
| Tumour size | +0.279 | 2.966 | 0.094 | |
| Miller–Payne grade | −0.325 | 4.140 | 0.050 |
Abbreviations: DOS=diffuse optical spectroscopy; ER=oestrogen receptor; GLCM=grey-level co-occurrence matrices; Hb=deoxy-haemoglobin; HbO2=oxy-haemoglobin; HbT=total haemoglobin; PR=progesterone receptor; StO2=tumour oxygen saturation; St=oxygen desaturation.
F-values are presented. Clinical features such as age, ER/PR status, Her2 status, and tumour size were not significantly correlated to DOS–GLCM features in this patient cohort. However, DOS–GLCM features such as the Hb-hom, HbO2-cor, StO2-con were correlated to Miller–Payne pathologic response grade. Statistically significant values are in bold.