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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2017 Jan 25;45:8–16. doi: 10.1016/j.ceb.2016.12.010

Figure 1. pHis Isomers and Structural Analogs.

Figure 1

Structural drawings of (A) the phosphoester amino acids; pSer, pThr and pTyr are contrasted with (B) histidine, 3-phosphohistidine (3-pHis) and 1-phosphohistidine (1-pHis). Examples of phosphohistidine structural analogs designed for antibody generation include; (C) phosphofurylalanine and the two phosphoryltriazolylalanine analogs (3-pTza) and (1-pTza). (D) Second-generation, pyrazole-based pHis analogs; 4-Phosphopyrazol-2-yl alanine (pPza) and phosphono-pyrazolyl ethylamine (pPye).