Table 1.
Patient Characteristics
| Demographics (N=66; Age 9.6 ± 5.1 years) | Percentage |
|---|---|
| Female | 65 |
| Caucasian | 86 |
| Type 1 AIH (ANA and/or ASMA) | 66 |
| Type 2 AIH (LKM) | 17 |
| Seronegative AIH | 17 |
| Co-morbid conditions: Thyroid disease | 6 |
| *Other disease | 12 |
| Symptoms and Signs at Presentation (N=59) | Percentage |
| Jaundice | 66 |
| Fatigue | 54 |
| Abdominal pain | 39 |
| Abdominal distention | 15 |
| Fevers | 12 |
| Pruritus | 10 |
| Weight loss/gain | 10 |
| Asymptomatic | 10 |
| Hepatomegaly | 41 |
| Splenomegaly | 24 |
| Jaundice | 30 |
| Ascites | 6 |
| Normal exam | 39 |
| Laboratory Values at Presentation (N=62) |
Mean ± S.D. (Normal Range) |
| Total protein (g/dL) | 7.8 ± 1.3 (5–8) |
| Albumin (g/dL) | 3.5 ± 0.8 (3.5–5.5) |
| Total bilirubin (mg/dL) | 5.6 ± 6.2 (0.2–1.2) |
| Direct bilirubin (mg/dL) | 3.7 ± 4.8 (0–0.3) |
| Alkaline phosphatase (U/L) | 399 ± 365 (45–150) |
| AST (U/L) | 1071 ± 1120 (10–50) |
| ALT (U/L) | 1024 ± 989 (10–50) |
| GGT (U/L) | 123 ± 101 (5–25) |
| INR | 1.37 ± 0.44 (0.9–1.1) |
| Platelets (count × 103/μl) | 251 ± 97 (150–500) |
| Total IgG (mg/dL) (N=42) | 2385 ± 1593 (400–1600) |
*
1 each: status post bone marrow transplant for leukemia or sickle cell anemia, autoimmune hemolytic anemia, food-protein induced enterocolitis syndrome, spina bifida, protein C deficiency, recurrent pancreatitis, vitiligo.