(A) Immunoblotting for acetylated lysine residues in whole cell and mitochondrial extracts of cells in the presence or absence of 5 mM malonate for 24h. Total protein staining by amido black shown as loading control.
(B-C) Immunoblotting for malonylated (B) and succinylated (C) lysine residues in mitochondrial extracts of ACSF3 KO and control cells treated with 5 mM malonate, 5 mM 3-nitropropanoate (3-NP, SDH suicide inhibitor), or both for 24h. See also Figure S5.