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. Author manuscript; available in PMC: 2017 Jun 24.
Published in final edited form as: Adv Exp Med Biol. 2016;903:113–128. doi: 10.1007/978-1-4899-7678-9_8

Fig. 8.1.

Fig. 8.1

A genome-wide scan of allelic differentiation between population samples of Tibetans (resident at 3200–3500 m in Yunnan Province, China) and Han Chinese. The vertical axis of the graph shows the negative log of site-specific P-values for allele frequency differences between the Tibetan and Han Chinese population samples (low P-values denote allele frequency differences that are too large to explain by genetic drift). The horizontal axis of the graph shows the genomic positions of each assayed nucleotide site, arranged by chromosome number. The red line indicates the threshold for genome-wide statistical significance (P = 5 × 10−7). Values are shown after correction for background population stratification using an intragenomic control. Several noncoding variants flanking the EPAS1 gene are highly significant outliers. Reprinted from [5]