Fig. 8.2.

Functional enrichment of transcriptional modules that are associated with thermogenic performance in deer mice. Categorical enrichments are shown for five separate modules that are associated with thermogenic capacity (cold-induced VO₂ max) (T21), thermogenic endurance (the length of time individuals can maintain >90 % of VO₂ max (T5 and T14), or both measures of performance (P4 and T16). Modules T5, T14, T16, and T21 are comprised of genes that differ in expression across rearing environments independent of population of origin, whereas module P4 is comprised of genes differ in expression between highland and lowland mice across rearing environments. For each performance-associated transcriptional module, the proportional representation of genes in different gene ontology categories is compared between the transcriptional module (gray bars) and the genome as a whole (black bars). Asterisks denote gene ontology categories that are significantly enriched within the transcriptional module (*uncorrected p < 0.05, **FDR corrected q < 0.05). Reprinted from [16]