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. 2017 Jun 23;7:4153. doi: 10.1038/s41598-017-03592-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BDNF is the molecule responsible for CM-induced axonal elongation in distal cortical axons. (A–C) Quantification of axonal outgrowth with the MATLAB script AxoFluidic. Profile along the xx axis of the microfluidic device showing the area occupied by the axons at 0 hours (clear red area) and at 24 hours (clear green area). Red line represents axonal projection at 0 hours and the green line represents axonal projection at 24 hours. (D) Quantification of axonal projections outgrowth between 0 and 24 hours. Distal axons treated with CM for 24 hours present more pronounced elongation than control or CM-lacking BDNF axons. Bars represent the mean ± SEM of 6 microfluidic chambers randomly selected of 3 independent experiments. *Represents p = 0.0346 by one-way ANOVA analysis of variance using Tukey post test when Ctr is compared to CM; ^#represents p = 0.0145 by one-way ANOVA analysis of variance using Tukey post test when CM is compared to CM + TrkB Fc.