Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 23;7:4122. doi: 10.1038/s41598-017-04547-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

In vivo imaging of vaccine antigen expression at the site of injection. (a) Representative in vivo bioluminescent images of luciferase expression in macaque skin at day 0, 1 and 7 after intradermal injection of auxoGTU^®-luc-EGFP ± EP. (b) Quantification of luciferase expression after vaccination with (n = 10) or without electroporation (n = 3). Mann-Whitney test. (c) In vivo fibered confocal microscopy showing EGFP expression by auxoGTU^® in the epidermis and the dermis after vaccination ± EP. Scale bar: 100 µm. (d) Quantification of EGFP⁺ cells from 4 to 96 h after vaccination, from 10 different frames. Paired and unpaired t-test. (e) Distribution of EGFP⁺ cells in the epidermis and the dermis after DNA vaccination with electroporation. Data are presented as mean ± SD; *p < 0.05; **p < 0.01; ***p < 0.001; EP, electroporation.