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. 2017 Jun 23;7:4135. doi: 10.1038/s41598-017-04509-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of prednisolone on mitochondrial reactive oxygen species (ROS). (A) Representative flow cytometry plots for hCECs after staining with CellROX^TM Deep Red and MitoTracker Green dyes. (B–D) Quantitative flow cytometry results for CellROX⁺MitoTracker⁺ cells as a measure of mitochondrial ROS in hCECs treated with prednisolone. The glucocorticoid receptor (GR) antagonist RU-38486 was added to some cultures (C). The mitochondrial ROS was also measured in hCECs transfected with GR siRNA or control SCR siRNA (D). Data are presented as mean ± SD from at least four independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant.