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. 2017 Jun 23;7:4163. doi: 10.1038/s41598-017-04177-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of SOAT1 and SOAT2 by BeauIII in an enzyme-based assay using microsomes from SOAT1- and SOAT2-CHO cells disrupted by sonication. SOAT1-/SOAT-CHO cells were sonicated for 3 (A), 5 (B), and 10 min (C). Microsomes were prepared from the disrupted cells, and used as enzyme sources for the SOAT1 (●) and SOAT2 (■) assays. The results obtained were plotted as % of control (without drugs). Values represent means ± SD (n = 3~4).