Table 3.

Pharmacokinetic parameters of commercial tablets, NI loaded NLR, NI loaded NSR, NI loaded NS after intragastric administration in rats, mean ± S.D., n = 6.

Parameter	Commercial tablets (10 mg/kg p.o.)	NLR (10 mg/kg p.o.)	NSR (10 mg/kg p.o.)	NS (10 mg/kg p.o.)
AUC(0-∞) (mg·h/L)	383.9 ± 84.1	817.1 ± 231.8	603.3 ± 205.6	543.2 ± 211.8
Cmax (mg/L)	2.7 ± 1.0	7.0 ± 1.4	3.8 ± 0.8	3.5 ± 1.1
Tmax (min)	28.3 ± 4.1	12.5 ± 2.7	12.5 ± 5.2	17.5 ± 6.9
t1/2 (min)	84.7 ± 39.6	93.2 ± 43.9	197.1 ± 119.0	150.0 ± 82.0
Rel. bioavailability	100.0%	212.8%	157.1%	141.8%