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. 2017 Jun 23;7:4144. doi: 10.1038/s41598-017-04379-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The number of branches in each of the ten bins in the tree maps. Graphs represent arterial (top left) and venous (bottom left) tree maps. Line and dots within the boxes represent the median and mean respectively. There are significantly fewer branches in the FGR arterial trees around the level of the 8^th bin of branches compared to normal while there is no difference in the number of branches in the venous trees. Curves on the top and bottom right represent the relationship between the median number of branches in the arterial and venous trees respectively. There is a trend suggesting fewer number of branches in the 4^th–10^th bins of branches in the FGR arterial trees (top right). This trend is absent in the venous trees (bottom right). Data presented as boxplots showing the median, range and interquartile range. n = 12 normal (6 arterial, 6 venous) and 12 FGR (6 arterial, 6 venous) casts. Two-way RM Anova with Sidak’s multiple comparison test, alpha value = 0.05, *marks two-tailed p value = 0.002.