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. 2017 Jun 23;7:4214. doi: 10.1038/s41598-017-04086-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MicroRNA-134 (miR-134) targets IL-18 binding protein (IL-18BP). (a) The potential target for miR-134 was IL-18BP. Sequence alignment of miR-134 with reverse complementary IL-18BP (http://www.microrna.org). (b) 293 T cells were co-transfected with IL-18BP 3′UTR wild type (WT), IL-18BP 3′UTR mutant or empty pMIR-REPORT vector and pTK-RL plasmid, together with miR-134 mimic/mimic control or miR-134 inhibitor/inhibitor control. After 36 h, luciferase activities were measured and normalized by Renilla luciferase activity. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01. NS, non-statistical significant. Comparison of supernatant levels of IL-18BP (c) or IL-18 (d) released in THP-1 cells transfected with miR-134 mimic, miR-134 inhibitor, mimic/inhibitor control, or non-transfection cells (mock). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, versus miR-134 inhibitor, mimic/inhibitor control, or non-transfection cells (mock), determined by the Student’s t-test.