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. 2017 Jun 23;7:4156. doi: 10.1038/s41598-017-04537-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of migratory capacity of thymocytes and T cells from DKO mice. (A–C) Chemotaxis assays with increasing concentrations of S1P, CXCL12, and CCL19 as indicated. Shown are the percentages of DP (A), CD4 SP (B), and CD8 SP (C) thymocytes that specifically migrated. (D) Chemotaxis assays with increasing concentrations of S1P, CXCL12, and CCL19 as indicated. Shown are the percentage of CD8 SP thymocytes either pre-treated with pertussis toxin (PTX), or not, that specifically migrated. (E) Chemotaxis assays with increasing concentrations of CXCL12 or CCL19 as indicated. Shown are percentages of CD4, CD8, and PTX toxin treated CD8 cells that specifically migrated. Results are 4 mice of each genotype done in duplicate. *p < 0.05, **p < 0.005 and ***p < 0.0005 (Student’s t-test).