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. 2017 Jun 23;7:4121. doi: 10.1038/s41598-017-04356-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The cell type compositions across lifespan in human brains, estimated using the DR-based deconvolution. The dots show the estimated proportions of samples, and the curves show the spline interpolation results. The left panel shows the cell type composition in human fetal brains, based on the human embryonic developmental brain RNA-seq data from BrainSpan; the right panel shows the cell type composition in human postnatal brains, based on the human postnatal brain data set. The bottom-right panels show proportions of OPC and oligodendrocytes in the human postnatal samples.