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. 2017 Jun 23;7:4121. doi: 10.1038/s41598-017-04356-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alteration of cell type composition in autism. (a) The estimated proportions of each cell types in autism case samples and healthy control samples with ages at the same age range. Each pair of boxes with the same color show the proportions of one cell type, with the left box represents the proportions in healthy samples, and the right box represents the proportions in autism samples. The plus signs mark significant difference according to Wilcoxon’s test (+− P < 0.1; ++−P < 0.05). (b) The disparity of observed altered non-neuron cell type compositions and the predicted altered compositions with the assumption of passive change of non-neuron cell type composition. Each box with a different color showed the observed altered proportion of one non-neuron cell type subtracted by the predicted altered proportion of the cell type based on the altered proportion of neurons scaled by the relative proportions of the non-neuron cell type in healthy samples.