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. 2017 Jun 23;7:4121. doi: 10.1038/s41598-017-04356-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Composition-dependent and independent transcriptome alteration in autism. (a) The number of genes with autism alterations in each component or the bulk expression levels (blue – bulk expression levels; pink – composition-dependent component; green – composition-independent component). The plus signs mark the significance of overlap (+++− Fisher’s exact test P < 0.0001). (b–d) Functional characterizations of genes with autism alterations in the composition-independent components, including GO enrichments (b), cell type expression enrichments (c) and enrichments of autism-associated genes (d). The bars show the log10-transformed P-values. The values within brackets in the button right panel show the numbers of all associated genes (right) and the sizes of the overlap with genes with autism alterations in their composition-independent components (left).