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. 2017 Jun 23;7:4148. doi: 10.1038/s41598-017-04176-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The proliferation and migration promoting effect of KIF4A in HCC cell lines. KIF4A expression was suppressed by RNAi in mRNA (a) and protein (b) level (upper panel, KIF4A protein expression in HCC-LM3 and PLC/PRF/5 cell lines; lower panel, each time point protein expression of KIF4A in HCC-LM3 cell line); KIF4A knockdown decreased cell proliferation rate of HCC-LM3 (c) and PLC/PRF/5 (d); KIF4A knockdown impaired migration rate in HCC-LM3 (e) and PLC/PRF/5 (f).