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. 2017 Jun 23;17:148. doi: 10.1186/s12862-017-0994-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Phylogeny of vertebrate Insulin receptor substrate (Irs) gene family sequences. Phylogeny of Irs sequences from diverse vertebrate species generated by Maximum likelihood using IQ-tree [49]. A similar phylogeny was generated by Bayesian methods [50, 51] (see Additional file 8: Figure S6). Phylogeny was rooted with sequences from acorn worm, purple sea urchin, and Florida lancelet (labeled as outgroups). Selected Irs sequences were chosen to represent the diversity of vertebrates, with different vertebrate Irs genes identified on the right. Similar results were obtained if other Irs sequences were used. Numbers at the nodes bootstrap support. Branch lengths are proportional to the inferred amount of change, with the scale bar at the bottom right. Diamonds indicate gene duplication events