Fig. 2.

Genomic organization of genes near Irs genes in the mouse and zebrafish genomes. The relative organization and orientation of genes near insulin receptor substrate (Irs) genes in (a) mouse and (b) zebrafish. Chromosomes and genomic locations are from Ensembl [44] (see Additional file 1: Table S1). Irs genes are labeled in red. Gene sizes and distances between genes are not to scale. Arrowheads indicate direction of transcription. Gene symbols are: Irs1–4, insulin receptors substrates 1–4; Col4a1–6, collagen, type IV, alpha1–6; Rhbdd1, rhomboid domain containing 1; Nyap2, Neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2; Myo16, Myosin XVI; Fbxo24, F-box protein 24; Lrch4, Leucine-rich repeats and calponin homology (CH) domain containing 4; Agfp2, ArfGAP with FG repeats 2; Nyap1, Neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1; Gucy2f, Guanylate cyclase 2f; Ankrd10, Ankyrin repeat domain 10; Ankrd46, Ankyrin repeat domain 46; Cars2, Cysteinyl-tRNA synthetase 2; Lig4, Ligase IV, DNA, ATP-dependent; Fam155a, Family with sequence similarity 155, member A; Pafah1b2, Platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; Rnf214, Ring finger protein 214; Gnb2, Guanine nucleotide binding protein (G protein), beta 2; Acap1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; Dvl2, Dishevelled segment polarity protein 2; Acadvl, Acyl-Coenzyme A dehydrogenase, very long chain; Atg4a, Autophagy related 4A, cysteine peptidase; Htr2c, 5-hydroxytryptamine (serotonin) receptor 2C