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. 2017 Jun 1;10(6):787–796. doi: 10.1242/dmm.025692

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Effect of P4 on mitochondrial complexes and oxidative parameters. Analysis of the levels of mitochondrial complexes in isolated mitochondria from the frontal cortex of the brain (n=6 in each group). (A) Effect of P4 on NADH dehydrogenase (complex I). ***P<0.001 versus sham, ^###P<0.001 versus tMCAO. (B) Effect of progesterone on succinate dehydrogenase (complex II). ***P<0.001 versus sham, ^##P<0.01 versus tMCAO. (C) MTT assay was done to assess the metabolic activity of cells in the frontal cortex of the brain (n=6). ***P<0.001 versus sham, ^#P<0.05 versus tMCAO. (D) Effect of P4 on F1-F0 synthase activity (complex V). ***P<0.001 versus sham, ^##P<0.01 versus tMCAO. (E) Effect of P4 on mitochondrial lipid peroxidation. ***P<0.001 versus sham, ^###P<0.001 versus tMCAO. (F) Effect of P4 on mitochondrial GSH. ***P<0.001 versus sham, ^##P<0.01 versus tMCAO.