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. 2017 Jun 1;10(6):787–796. doi: 10.1242/dmm.025692

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Effect of P4 on histopathology. (A-C) Representative histopathological photomicrograph of frontoparietal layers of the sham, tMCAO and tMCAO+P4 group. In the sham group, there was no vacuolation or any neuronal loss. In the tMCAO group, there was vacuolation and heavy neuronal loss. In the P4 treated group there was the partial neuronal loss. Magnification at 40×. (D) Histological alterations are represented graphically, showing significant changes (**P<0.001) in tMCAO and that, in the P4 treated group, there was a significant improvement (^#P<0.05).