Fig. 2.

Brain regions showing similarities and differences during laser- and suggestion-induced pain and time courses of the BOLD signal. (A) Brain regions activated during both suggestion- and laser-induced pain. A liberal threshold of P < 0.05 is used to illustrate the activation trend in cACC. (B) The (mean ± SEM across subjects) time courses of signal changes in the encircled brain areas of A during laser- (Left) and suggestion-induced pain (Right). Only the first three and the last three time points of the suggestion periods are illustrated, because time to pain appearance and to pain relief varied among subjects. Sugg on, suggestion for pain; Sugg off, suggestion for pain relief. (C) Areas where activation was stronger during laser- than suggestion-induced pain. (D) The signal time courses from the areas encircled in C.