Table 1. Correlation (R) between activation strengths and subjective reality of pain across subjects.
| Brain region | x | y | z | R | Peak Z | P | Volume, mm3 |
|---|---|---|---|---|---|---|---|
| Suggestion-induced | |||||||
| Bilateral rACC | 8 | 36 | 20 | 0.85 (0.64) | 3.9 (2.4) | 0.001* (0.01) | 910 (1600) |
| -8 | 32 | 19 | 0.83 (0.63) | 3.7 (2.3) | 0.001* (0.01) | 470 (380) | |
| Pericingulate cortex | -6 | 48 | 22 | 0.81 (0.51) | 3.5 (1.8) | 0.001* (0.03) | 1,170 (180) |
| Right pACC | 8 | 43 | 0 | 0.73 (0.74) | 3.4 (2.9) | <0.001 (0.002) | 300 (260) |
| Laser-induced | |||||||
| Left rACC | -8 | 36 | 20 | 0.69 (0.58) | 2.7 (2.1) | 0.003 (0.02) | 2,370 (2420)† |
| Left pACC | -4 | 48 | 4 | 0.48 (0.55) | 1.7 (2.5) | 0.04 (0.007) | 90 (260)† |
| Bilateral SII | 65 | -17 | 19 | - (0.41) | - (2.3) | - (0.01) | - (730)† |
| -56 | -20 | 19 | - (0.36) | - (1.8) | - (0.03) | - (90)† | |
| Bilateral posterior insula | 42 | -11 | 6 | - (0.45) | - (2.2) | - (0.01) | - (410)† |
| -44 | -13 | -8 | - (0.43) | - (2.3) | - (0.01) | - (530)† |
x, y, and z are Talairach coordinates, and Z is t value transformed into normal distribution. Volume consists of voxels where P < 0.005 (uncorrected) or P < 0.05 (†, uncorrected). All values within parentheses derive from multiple-regression analysis, where intensity and unpleasantness were included as confounding factors; the correlation between sensory pain-processing areas and subjective reality of pain was found only in this analysis. BA, Brodmann's area.
*
Corrected for multiple comparisons